Chemical analysis carried out using the very common hyphenated technique of gas chromatography mass spectrometry (GC-MS), may have been generating spurious data for half a century, according to work carried out by scientists at The Scripps Research Institute in California. Gary Siuzdak and colleagues believe they have found that GC-MS fundamentally alters the samples it analyzes leading to transformations and loss of small molecules during analysis. It seems that four out of every ten molecules that might be analyzed by GC-MS would be affected. They suggest it is time for science to cool off and use ambient temperature MS so that thermal degradation does not occur.
Weighing up a fundamental flaw