Turbo transfer

Thomas Carell and colleagues at Munich's Ludwig Maximilians University, Germany, have introduced a novel method for synthesizing transfer RNA (tRNA) nucleosides. tRNA nucleosides are modified genetic bases and include deazaguanosine nucleosides, which have antibacterial, antifungal, antiviral, and anticancer activity. The team has applied a Turbo-Grignard-based approach to their synthesis and demonstrated an unprecedented level of control of the products they can derive from a common intermediate, thus overcoming the problem of multiple reactive groups in the deazaguanosine nucleosides. Specifically, the team was able to synthesize the PreQ1, PreQ0, and archaeosine.