Painkiller is just a number

Compound 37, or V116517, the drug with no name, is an early-stage experimental analgesic that works by blocking the protein that normally makes red-hot chili peppers burn one's mouth. The protein in question, TRPV1, is present in human nerves and while it senses the spice in chili peppers caused by the chemical capsaicin, it also senses heat pain, the burning of strong acids and molecules linked to tissue inflammation in some forms of arthritis and irritable bowel syndrome. Details of compound 37, or to give it its systematic name, 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide, and the structure-activity relationships are published in the Journal of Medicinal Chemistry.