The apparently simple molecule hydrogen peroxide plays a complex role in health. Now, researchers at Wake Forest University School of Medicine have uncovered how H2O2 plays its part. For example, when the immune system is activated in response to the presence of bacteria, large amounts of hydrogen peroxide are released by certain cells to fight the infection. Now, Todd Lowther and colleagues have obtained a crystal structure that shows how two proteins produced by cells interact to regulate the levels of hydrogen peroxide. The research could help us understand what goes wrong in certain disease states and may lead ultimately to new avenues for therapy in a range of diseases.
H2O2 and all that