A hybrid hydrogel comprising an Fmoc-diphenylalanine (Fmoc-FF) peptide and konjac glucomannan (KGM) has been developed and characterized by researchers in China. They have now successfully described the material's ability to take up and release a drug molecule, the cancer chemotherapy agent, docetaxel. Uptake and release rates could be tuned by starting with different concentrations of KGM, the team says. They used electron microscopy to study the morphology of the hydrogels and this allowed them to describe in detail the uptake and release processes pointing them towards a way to optimize the hydrogel for further tests and ultimately clinical trials.
Gelatinous drug delivery