Energy budgets

The enzyme adenylate kinase is vital to the management of the energy budget in our cells. Now scientists from the Universities of Konstanz, Germany and Umeå University in Sweden, have investigated the closed state of this enzyme in detail using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography. They have thus constructed a structural model at the atomic level of the enzyme docked to its ligand. Writing in the journal Proceedings of the National Academy of Sciences (PNAS), the team explains how the work is providing new insights into metabolism with potential for new avenues of research into therapeutics for metabolic disease.