How to copy DNA

Researchers at Umeå University in Sweden have demonstrated how the DNA polymerase epsilon enzyme builds new genomes. The detailed image they obtained using X-ray crystallography. The structure of the polymerase that we have solved makes it possible to see where these mutations lead to changes in the structure of DNA polymerase epsilon, explains Erik Johansson. This can help us to understand why a certain mutation contributes to the development of a certain cancer. Specifically, the new research shows how mutations that can contribute to the development of colorectal cancer and cervical cancer lead to changes in the structure of the protein.