The hunt for molecular diversity among vast libraries of natural products as putative antibiotics could get easier thanks to the BioMAP screen procedure developed by a team at the University of California, Santa Cruz. Antibiotic resistance has been known since the earliest times these drugs were first used but has become a widespread problems especially in hospitals where so-called superbug infections threaten patients with infections that do not respond to known antibiotics. There is thus a pressing need to find new drug candidates with novel structures and diverse modes of action that could stave off resistance once again. If you take a library of natural product extracts and screen them against a bacterial target, you will find a lot of antibacterial compounds, but almost all of them will be known structures, said Roger Linington. BioMAP avoids the knowns and looks only for unknowns.
Big screen antibiotics