Annals of Nuclear Medicine (v.28, #3)
Electrocardiographically gated 11C-hydroxyephedrine PET for the simultaneous assessment of cardiac sympathetic and contractile functions by Keiichi Magota; Naoya Hattori; Osamu Manabe; Masanao Naya; Noriko Oyama-Manabe; Tohru Shiga; Yuji Kuge; Shiro Yamada; Mamoru Sakakibara; Keiichiro Yoshinaga; Nagara Tamaki (187-195).
Application of the electrocardiographically (ECG) gated positron emission tomography (PET) technique with 11C-hydroxyephedrine (HED) would allow the simultaneous assessment of cardiac sympathetic and contractile functions. However, there are uncertainties regarding the diagnostic accuracy of left ventricular (LV) volume measurements using ECG-gated HED-PET. The purpose of this study was to clarify the minimal requirement of count statistics to measure LV volumes with ECG-gated HED-PET and to investigate the reliability of the measurements.Five healthy volunteers and 11 patients with heart failure underwent a 40-min list-mode PET scan after an injection of HED (197 ± 35 MBq). The list-mode data were histogrammed into multiple sets of acquisition periods at 0.5, 1.0, 2.0, 4.0, 6.0, 8.0, 12.0 Mcount/bin and reconstructed into corresponding gated images using an iterative algorithm. The LV end-diastolic volume (LVEDV), the LV end-systolic volume (LVESV), and the LV ejection fraction (LVEF) were calculated in each acquisition period. These values were compared with those obtained by cardiac magnetic resonance imaging (MRI). Possible effects of HED retention on the accuracy of the volume measurements were investigated.Collecting less than 4.0 Mcount/bin resulted in noisy cardiac images. The lower counts resulted in underestimation in the volume measurements. Reasonably accurate volume measurements required equal to or greater than 6.0 Mcount/bin. This corresponded to 7.0 ± 1.9 min (range, 4.0–10.3 min) for the acquisition period. Volumetric results using the 6.0 Mcount/bin data highly correlated with cardiac MRI (LVEDV: r = 0.85, p < 0.0001; LVESV: r = 0.89, p < 0.0001; LVEF: r = 0.77, p < 0.01). The HED retention did not affect the volumetric results compared to the MRI volumetry.The volumetric accuracy with ECG-gated HED-PET was affected by the count statistics rather than the HED retention. LV volume measurements were feasible with 10-min acquisition period for most of the patients. This technique allows the simultaneous assessment of cardiac sympathetic and contractile functions without the need for an additional injection or scanning time, thus reducing overall costs for diagnostic imaging.
Keywords: Positron emission tomography (PET); 11C-hydroxyephedrine (HED); Cardiac gating; Left ventricular volume; Left ventricular ejection fraction
Predictive value of volumetric parameters measured by F-18 FDG PET/CT for lymph node status in patients with surgically resected rectal cancer by Hong Jae Jo; Seong-Jang Kim; In Joo Kim; Sojung Kim (196-202).
The objective of this study was to investigate the predictive role of volumetric parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by F-18 FDG PET/CT for regional lymph node (rLN) metastasis in rectal cancer patients.Retrospectively, 74 rectal cancer patients were enrolled. All patients received surgical treatment and F-18 FDG PET/CT at diagnosis. The F-18 FDG PET/CT findings of primary cancer and rLN involvement were compared with the pathologic diagnosis within 5 weeks after operation. Univariate and multivariate analyses were used to analyze the associations among the pathologic LN status and age, sex, T stage, AJCC stage, SUVmax, lymphatic invasion, venous invasion, neural invasion, and volumetric parameters.The LN (+) group showed statistically significant higher values of MTV2.5 (p < 0.0001), MTV3 (p < 0.0001), MTV3.5 (p = 0.0001), TLG2.5 (p = 0.0007), TLG3 (p = 0.0011), and TLG3.5 (p = 0.0024). In univariate analysis, T stage, AJCC stage, neural invasion, and volumetric parameters were factors significantly associated with pathologic LN involvement. However, in multivariate analysis, advanced T stage, high AJCC stage, MTV2.5, and TLG2.5 were associated with pathologic LN involvement in rectal cancer.This study showed that, not only T stage and AJCC stage, but also volumetric parameters such as MTV2.5 and TLG2.5 are useful factors for the prediction of pathologic LN status in rectal cancer patients.
Keywords: F-18 FDG PET/CT; MTV; TLG; Rectal cancer; Lymph node
Diagnosis of dementia with Lewy bodies: diagnostic performance of combined 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy by Fumi Sakamoto; Shinya Shiraishi; Morikatsu Yoshida; Seiji Tomiguchi; Toshinori Hirai; Tomohiro Namimoto; Mamoru Hashimoto; Manabu Ikeda; Hiroyuki Uetani; Yasuyuki Yamashita (203-211).
We assessed the value of combining 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy for the discrimination of dementia with Lewy bodies (DLB) from other types of dementia. We subjected 252 consecutive patients with clinically suspected DLB to both 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial scintigraphy. Patients with Parkinson’s disease were included. The 252 patients were randomly assigned to an estimation (n = 152) or a validation group (n = 100). Using univariate analysis, we first analyzed the relationship between various variables and the presence or absence of DLB in estimation group and then proceeded to multivariate analysis to obtain a combined index that predicted the likelihood of DLB. The diagnostic value of the index was assessed by calculating the area under the receiver operating characteristic (ROC) curve (AUC) with the cutoff value selected from the ROC curve. We then tested the predictive accuracy of the index in validation group. The combined index was an arithmetic expression that combined the age, early 123I-MIBG heart-to-mediastinum uptake (E-H/M) ratio, and the parietal lobe hypoperfusion score. Values for the AUC of the combined index, the E-H/M ratio, the parietal lobe hypoperfusion score, and the patient age in validation group were 0.95, 0.90, 0.72, and 0.73, respectively. There was a significant difference in the AUC of the combined index among other indices (p < 0.05). The sensitivity, specificity, and accuracy of the combined index for a diagnosis of probable DLB in validation group were 88, 87, and 87 %, respectively.The combinational diagnosis based on 123I-IMP brain perfusion SPECT, 123I-MIBG myocardial scintigraphy, and the patient age is a simple and reliable means for predicting probable DLB.
Keywords: Dementia with Lewy bodies; 123I-IMP brain perfusion SPECT; 123I-MIBG myocardial scintigraphy; Combined index
Detection of colorectal cancer and adenomas by FDG-PET cancer screening program: results based on a nationwide Japanese survey by Ryogo Minamimoto; Michio Senda; Seishi Jinnouchi; Takashi Terauchi; Tsuyoshi Yoshida; Tomio Inoue (212-219).
The aim of this study was to analyze the detection rate for CRC and adenomas for asymptomatic subjects in Japan by FDG-PET cancer screening program carried out between 2006 and 2009.The “FDG-PET cancer screening program” included both PET and positron emission tomography with computed tomography (PET/CT) with or without other screening tests. A total of 154,783 asymptomatic subjects underwent FDG-PET cancer screening program; we analyzed the 1,808 cases with findings from any detection method that indicated suspected CRC.Among the 1,808 cases, the number of cases verified as CRC and adenoma was 394 and 679, respectively. The sensitivity and positive predictive value (PPV) of FDG-PET were 86.0 and 31.7 % for CRC, and 63.6 and 63.8 % for CRC and adenoma. The sensitivity and PPV of fecal occult blood test (FOBT) for CRC were lower than those of FDG-PET, but higher for adenoma. Therefore, FDG-PET and FOBT were complementary for screening for CRC, and CRC and adenoma. The majority of CRC detected by the FDG-PET imaging was UICC stage 0 or I, however, detection of smaller or less invasive cancer was limited.The FDG-PET screening program in Japan has detected CRC at an early stage and adenomas as premalignant lesions. A combination of FDG-PET and FOBT yields the best results if the intent is to detect either CRC or adenoma. However, it is absolutely clear that an FDG-PET cancer screening program cannot detect all colon lesions.
Keywords: FDG; PET; PET/CT; Cancer screening; Colon/rectal cancer (CRC); Adenoma
Age-related decline in dopamine transporter in human brain using PET with a new radioligand [18F]FE-PE2I by Yoshitoshi Shingai; Amane Tateno; Ryosuke Arakawa; Takeshi Sakayori; WooChan Kim; Hidenori Suzuki; Yoshiro Okubo (220-226).
Dopamine transporter (DAT) density is considered as a marker of pre-synaptic function. Numerous neuroimaging studies have consistently demonstrated an age-related decrease in DAT density in normal human brain. However, the precise degree of the regional decline is not yet clear. The purpose of this study was to evaluate the effect of the normal aging process on DAT densities in human-specific brain regions including the substantia nigra and thalamus using positron emission tomography (PET) with [18F]FE-PE2I, a new PET radioligand with high affinity and selectivity for DAT.Thirty-six healthy volunteers ranging in age from 22 to 80 years were scanned with PET employing [18F]FE-PE2I for measuring DAT densities. Region of interest (ROI)-based analysis was used, and ROIs were manually defined for the caudate, putamen, substantia nigra, thalamus, and cerebellar cortex. DAT binding was quantified using a simplified reference tissue model, and the cerebellum was used as reference region. Estimations of binding potential in the caudate, putamen, substantia nigra, and thalamus were individually regressed according to age using simple regression analysis. Estimates of DAT loss per decade were obtained using the values from the regression slopes.There were 7.6, 7.7, and 3.4 % per-decade declines in DAT in the caudate, putamen, and substantia nigra, respectively. By contrast, there was no age-related decline of DAT in the thalamus.[18F]FE-PE2I allowed reliable quantification of DAT, not only in the caudate and putamen but also in the substantia nigra. From the results, we demonstrated the age-related decline in the caudate and putamen as reported in previous studies, and additionally for those in the substantia nigra for the first time.
Keywords: [18F]FE-PE2I; Human; Positron emission tomography (PET); Dopamine transporter (DAT); Aging
Quantitative sacroiliac scintigraphy for pediatric patients: comparison of two methods by Murat Fani Bozkurt; Pinar Kiratli (227-231).
Quantitative bone scintigraphy is a useful method to diagnose sacroiliitis. However, there is significant overlap between healthy and pathological sacroiliac index (SI) values for adult patients, while there are no such sufficient data for children. This study was aimed mainly to assess normal SI values in different age groups of pediatric patients using 2 different quantitative methods.Normally reported bone scans of 79 children were retrospectively reviewed. Two different methods were used for quantitation. For the first method, sacrum was used as a background site while L5 vertebra was used instead for the second method. Right/left SI values of both methods were compared with each other in relation with gender and different age groups, as group 1 (1–5 years), group 2 (6–10 years), group 3 (11–15 years) and group 4 (16–18 years). Additional comparison was made with a group of young-adult population of 21–30 years old as group 5 to assess the effect of age.Gender-based comparison yielded significantly higher SI for females for the first method, while no significant difference existed for the second one. Significant increase in SI with both methods was found as age increased. Significantly lower SI was found from the second method, when similar age groups like group 1–2 or group 2–3 were compared with each other, while no such difference existed for the first method. For each individual patient from any age group, method-based comparison resulted in a significantly different SI with both methods.In pediatric population, SI tends to increase as age increases. Quantitation method using sacrum as background yields significantly higher SI for female gender. Alternative use of L5 as background site for quantitation performs well in children. Since two methods resulted in significantly different SI, individualized cut-off values for each age group for any method are practically warranted.
Keywords: Children; Sacroiliitis; Scintigraphy; Age; Gender
Development of a high-resolution YSO gamma camera system that employs 0.8-mm pixels by Seiichi Yamamoto; Hiroshi Watabe; Yasukazu Kanai; Katsuhiko Kato; Jun Hatazawa (232-240).
YSO (Ce-doped Y2SiO5) is a promising scintillator for a single-photon imaging system since it has relatively high light output and does not contain any natural radioactivity. Since YSO is not hygroscopic, it may be possible to fabricate a block with small pixels for a high-resolution system. For this purpose, we developed a high-resolution gamma camera system that employs smaller than 1-mm YSO pixels.The gamma camera’s detector used 0.8 × 0.8 × 7-mm YSO pixels. All the surfaces of these YSO pixels were mechanically polished, combined with a 0.1-mm-thick BaSO4 reflector to form a 48 × 48 matrix, and optically coupled to a high quantum efficiency, 2-inch square position sensitive photomultiplier tube (Hamamatsu Photonics H10966 A-100). The YSO block was 43.2 × 43.2 mm. The YSO gamma camera was encased in a 5-mm-thick tungsten container, and a parallel collimator was mounted on its front. The parallel hole collimator was made of a 3-layer (each layer was 5-mm thick) tungsten plate, and each plate had 48 × 48, 0.6-mm holes that were positioned by one-to-one coupling with the YSO pixels.Even with the 0.8-mm YSO pixels, we clearly resolved most of the pixels in a 2-dimensional histogram with a peak-to-valley ratio of 2.9 for the 122-keV gamma photons. The energy resolution was 20.4 % FWHM. The spatial resolutions with a parallel hole collimator 2 mm from the collimator surface were 0.7- and 1.3-mm FWHM for the 122- and ~35-keV gamma photons, respectively. We successfully obtained phantoms and small animal images with our YSO gamma camera system.Our high-resolution system has a potential to be useful for molecular imaging research.
Keywords: YSO; HQE PSPMT; Gamma camera; High resolution; Tungsten collimator
Diagnostic value of 18F-FDG PET/CT in patients with TENIS syndrome: correlation with thyroglobulin levels by Elif Özdemir; Nilufer Yildirim Poyraz; Sefika Burcak Polat; Seyda Turkolmez; Reyhan Ersoy; Bekir Cakir (241-247).
The aim of the study was to disclose the place of 18F-FDG PET/CT to predict recurrent disease in patients with differentiated thyroid cancer (DTC), negative radioiodine whole-body scan (WBS) and high serum thyroglobulin (Tg).Seventy-one patients who underwent total thyroidectomy followed by radioactive iodine ablation and had negative radioiodine WBS but elevated Tg levels underwent PET/CT. They were followed up for 6–50 months (median 23) for the occurence of recurrent disease as detected by either clinical findings, other imaging modalities or histopathological examination. The place of PET/CT findings at baseline to predict the presence of recurrent disease was evaluated. Correlation between PET/CT findings and Tg levels was examined and a threshold for Tg level above which the predictive value of PET/CT was highest was determined.PET/CT was positive for recurrent disease in 38 (53.5 %) patients. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of PET/CT to predict the occurence of recurrent disease at follow-up were 68.8, 78.3, 86.8, 54.5 and 71.9 %, respectively. The sensitivity, accuracy and PPV of PET/CT increased with increasing Tg levels. The highest diagnostic accuracy of PET/CT, with a sensitivity of 76.2 % and a specificity of 100 % to detect recurrent disease appeared to be at a Tg level greater than 29 ng/mL.Our findings suggest that 18F-FDG-PET/CT is a valuable tool to predict the occurence of recurrent disease in patients with DTC, negative WBS and elevated Tg levels. PET/CT positivity has been shown to be strongly and positively correlated with Tg levels in this patient subset.
Keywords: 18F-FDG-PET/CT; Thyroglobulin; Differentiated thyroid cancer; Radioiodine imaging
Studying the biological feasibility of [99mTc(CO)3]-dextran-cysteine-cysteine-mannose as a potential molecular radiopharmaceutical for sentinel node detection by Irfan U. Khan; Abubaker Shahid; Fayyaz Ahmad; Ume K. Dar; Munir Ahmad; Muhammad Javed (248-256).
The aim of this work was to radiolabel and bioevaluate the technetium-99m labeled dextran dicysteine mannose (DCCM) [99mTc(CO)3]-DCCM for sentinel lymph node detection.Dextran dicysteine mannose was radiolabeled using the carbonyl method. Various parameters were studied such as in vitro stability at room temperature up to 5 h, protein binding and partition coefficient. Bioevaluation was performed in a rabbit model by developing images under a gamma camera at various time intervals. Biodistribution was performed in Wistar rat models (n = 3) by dissection and measurement of percent injected dose in various body organs, at 60 and 180 min post-injection intervals. Biodistribution was performed in two different groups of animals: in the first group, the radiolabeled compound was injected at a concentration of 200 μg/ml, thus delivering 10 μg radiolabeled compound at the site of injection; in the second group, the radiolabeled compound was injected at a concentration of 50 μg/ml, delivering 2.5 μg radiolabeled compound at the site of injection.Radiolabeling efficacy was 97.5 ± 1 % which remained quite stable till 5 h. Protein binding data show that 71.1 ± 5 % drug exhibited binding with blood proteins. Partition coefficient results show that our radiopharmaceutical is quite hydrophilic in nature. It can be inferred from the imaging data that sentinel node can be visualized within 30 min post-injection. Rat dissection data showed that when the radiolabeled compound was injected at a concentration of 50 μg/ml, at 60 min post-injection, ~2.85 % of activity was retained in the sentinel node with a significantly less accumulation, e.g., ~0.12 %, in the secondary node, which resulted in very high popliteal extraction (PE) value, e.g., ~98 %. At 180 min post-injection, 2.46 ± 0.29 % was found to be retained in the sentinel node and PE (99.64 ± 0.23 %), thus resulting in almost complete washout from the secondary node (0.05 ± 0.01 %).The study demonstrates that radiolabeled DCCM might be a successful radiopharmaceutical for sentinel node detection.
Keywords: Dextran dicysteine mannose; Radiopharmaceutical; Nanoparticles; Popliteal extraction
18F-fluorodeoxyglucose positron emission tomography for evaluation of thymic epithelial tumors: utility for World Health Organization classification and predicting recurrence-free survival by Norio Seki; Setsu Sakamoto; Yoko Karube; Takeshi Oyaizu; Hiromi Ishihama; Masayuki Chida (257-262).
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) plays an important role in many oncological settings. In this study, we assessed the utility of 18F-FDG-PET for predicting the histological classification, stage and survival of thymic epithelial tumors.We retrospectively analyzed 37 patients with thymic epithelial tumors who underwent PET before surgical resection and investigated the relationship between the maximum of standardized uptake value (SUVmax) of each tumor and the WHO classification, recurrence-free survival, and tumor-related gene expressions.The study included 15 males and 22 females, ranging in age from 22 to 81 years (mean 64 years). The tumor histology of 31 tumors was thymoma and that of the remaining tumors was thymic carcinoma. The Masaoka tumor stage was as follows: stage I in 18, II in 9, III in 5 and IV in 5 patients. The patients were divided into three groups according to a simplified histologic classification: low-risk thymoma (types A, AB and B1, n = 21), high-risk thymoma (types B2 and B3, n = 10) and thymic carcinoma (n = 6). The SUVmax of low-risk group (SUVmax ≤4.27) was significantly lower than that of high-risk group (p = 0.0114) and that of thymic carcinomas (SUVmax >4.27) was also significantly higher than that of thymomas (p < 0.0001). The group of high SUVmax (SUVmax >4.27) had significantly inferior recurrence-free survival to that of less value (SUVmax ≤4.27) (p = 0.0009). The SUVmax were not correlated with tumor-related gene expressions.The SUVmax of 18F-FDG-PET reflects WHO classification of thymic epithelial tumors. High SUVmax predicts lower recurrence-free survival of the tumors.
Keywords: Thymoma; Thymic carcinoma; Positron emission tomography
Evaluation of the difference-correction effect of the gamma camera systems used by easy Z-score Imaging System (eZIS) analysis by Yasushi Yamamoto; Masahisa Onoguchi; Kazunori Kawakami; Masuo Haramoto; Rei Wake; Jun Horiguchi; Hajime Kitagaki (263-275).
We examined the difference of the effect by data to revise a gamma camera difference. The difference-correction method of the camera is incorporated in eZIS analysis.We acquired single photon emission computed tomography (SPECT) data from the three-dimensional (3D) Hoffman brain phantom (Hoffman), the three-dimensional brain phantom (3D-Brain), Pool phantom (pool) and from normal subjects (Normal-SPECT) to investigate compensating for a difference in gamma camera systems. We compared SPECT counts of standard camera with the SPECT counts that revised the difference of the gamma camera system (camera). Furthermore, we compared the “Z-score map (Z-score)”. To verify the effect of the compensation, we examined digitally simulated data designed to represent a patient with Alzheimer’s dementia. We carried out both eZIS analysis and “Specific Volume of interest Analysis (SVA)”.There was no great difference between the correction effect using Hoffman phantom data and that using 3D-Brain phantom data. Furthermore, a good compensation effect was obtained only over a limited area. The compensation based on the pool was found to be less satisfactory than any of the other compensations according to all results of the measurements examined in the study. The compensation based on the Normal-SPECT data resulted in a Z-score map (Z-score) for the result that approximated that from the standard camera. Therefore, we concluded that the effect of the compensation based on Normal-SPECT data was the best of the four methods tested.Based on eZIS analysis, the compensation using the pool data was inferior to the compensations using the other methods tested. Based on the results of the SAV analysis, the effect of the compensation using the Hoffman data was better than the effect of the compensation using the 3D-Brain data. By all end-point measures, the compensation based on the Normal-SPECT data was more accurate than the compensation based on any of the other three phantoms.
Keywords: 99mTc-ECD; 99mTc-HMPAO; SPM; eZIS; Image correction
18F-FDG PET/CT is a valuable tool for relapsing polychondritis diagnose and therapeutic response monitoring by Jinlin Wang; Shiyue Li; Yunxiang Zeng; Ping Chen; Nuofu Zhang; Nanshan Zhong (276-284).
To retrospectively investigate the role of 18 F–fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for the diagnosis and therapeutic response in relapsing polychondritis (RP) patients. 18F-FDG PET/CT findings were reviewed in six RP patients. The initial scans were performed for all patients, follow-up scans were performed during steroid therapy for five patients. Changes in the abnormal lesions and the maximal standard uptake value (SUVmax) were analyzed.The initial PET/CT scans revealed intense FDG uptake in the cartilages for all six patients. The lesions of abnormal FDG uptake were tracheal/bronchial cartilage (n = 4), costicartilage (n = 4), nasal cartilage (n = 3), cricoid cartilage (n = 3), auricular cartilage (n = 3), arytenoid cartilage (n = 3), thyroid cartilage (n = 2), hyoid cartilage (n = 1) and mediastinum lymph node (n = 1). The mean visual score and the mean SUVmax were 2.96 ± 0.20 and 4.10 ± 0.6. The intense uptake reduced or disappeared during steroid therapy for five patients, the mean visual score and the mean SUVmax were 1.58 ± 1.4 and 1.51 ± 1.4. 18F-FDG PET/CT enables the acquisition of both morphologic and glucose metabolic of the related cartilage structures. It plays a valuable role in assessing almost all cartilage and detecting RP, which is a better selection of a biopsy site as well as therapeutic response monitoring.
Keywords: Fluorodeoxyglucose; PET/CT; Relapsing polychondritis; Cartilage; Standard uptake value
Myocardial washout rate of resting 99mTc-Sestamibi (MIBI) uptake to differentiate between normal perfusion and severe three-vessel coronary artery disease documented with invasive coronary angiography by Bulin Du; Na Li; Xuena Li; Yaming Li; Bailing Hsu (285-292).
Patients with severe coronary artery disease (CAD) may present impaired mitochondrial function to enhance 99mTc-sestamibi (MIBI) washout from ischemic myocardium. In this study, we aimed to study the MIBI washout rate (WR) between patients with three-vessel CAD (3V-CAD) confirmed by invasive coronary angiography and healthy normal volunteers (HNV) to evaluate the potential utility of MIBI WR to differentiate between these two populations and to stratify the CAD severity.Ten HNV (male = 5, age = 56 ± 10 years) and eight 3V-CAD patients (male = 4, age = 62 ± 8 years) with 3V lumen stenosis ≥50 % were enrolled for this study. Each study subject had a resting MIBI perfusion scan at 90 min and a repeated scan at 4 h post the MIBI injection. Global WR (GWR) and regional WR (RWR) were quantified with the percentage difference of decay-corrected polar maps obtained from the two scans and compared between the HNV and 3V-CAD groups. For the 3V-CAD group, the severity of CAD was assessed with CAD severity scores (CADSS) utilizing degree and location of obstructive lesions (stenosis ≥50 %) for quantification and compared with WR to evaluate the correlation between these two variables.Significantly higher GWR was observed in the 3V-CAD (21.1 ± 4.6 %) group than the HNV group (9.5 ± 4.9 %) (p < 0.001). RWR values in left anterior descending (LAD), right coronary artery (RCA) and left circumflex (LCX) in the 3V-CAD group were also higher than those of the HNV group (LAD 20.7 ± 5.9 vs 9.4 ± 5.6, p < 0.001; RCA 21.3 ± 4.8 vs 9.2 ± 5.8, p < 0.001; LCX 20.5 ± 7.2 vs 10.1 ± 4.4, p = 0.002). Additionally, the linear correlation of GWR and total CADSS for the whole myocardium was strong and statistically significant (y = 0.86x − 1.12, r 2 = 0.73, p = 0.006).Patients with impaired mitochondrial function due to 3V-CAD had consistently higher global and regional rest 99mTc-sestamibi washout rates than those of healthy normal volunteers. The global rest 99mTc-sestamibi washout rate is a sensitive indicator to stratify the severity of 3V-CAD and to differentiate between severe 3V-CAD and normal perfusion populations.
Keywords: 99mTc-sestamibi; Washout rate; Mitochondrial dysfunction; Three-vessel coronary artery disease
Erratum to: 18F-FDG PET as a single imaging modality in pediatric neuroblastoma: comparison with abdomen CT and bone scintigraphy by Yun Jung Choi; Hee Sung Hwang; Hyun Jeong Kim; Yong Hyu Jeong; Arthur Cho; Jae Hoon Lee; Mijin Yun; Jong Doo Lee; Won Jun Kang (293-293).
Erratum to: Discrepancy of left and right hip bone mineral density (BMD) in Thai women: diagnostic agreement and misclassification by Sirianong Namwongprom; Sattaya Rojanasthien; Ampica Mangklabruks; Suppasin Soontrapa; Potjaman Taya; Boonsong Ongphiphadhanakul (294-294).