A new approach to NMR spectroscopy allows chemists to obtain more information than is usually possible about the structure of their compounds. Roberto Gil of Carnegie Mellon University in Pittsburgh and colleagues have used Residual Dipolar Couplings in the small molecule jaborosalactol 24, a potential anticancer drug, to work out its three-dimensional structure, something that would otherwise be possible only with diffraction techniques. They verified the structure with X-ray powder diffraction data. The NMR technique will be useful for compounds for which X-ray data are unavailable as well as offering a quicker and simpler structure determination.
Anticancer compound? Absolutely