The case for using green solvents in HPLC

Is it a good idea to replace HPLC solvents with greener alternatives with low performance capabilities? Christopher Welch and his colleagues at Merck Research Laboratories in Rahway, New Jersey, US, think so.

High performance liquid chromatography is the most widely-used analytical technique in the pharmaceutical industry and acetonitrile is by far the preferred HPLC solvent. 'A pharma company could have over a thousand instruments in operation,' explains Welch, who adds, 'While the amount of waste generated by an individual HPLC is small, the cumulative volume is substantial.'  More...

http://www.rsc.org/Publishing/ChemScience/Volume/2009/07/green_HPLC.asp