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Taming erythropoietin through synthesis
Chemists have realised a 10 year dream to synthesis from scratch the 166 amino acid protein EPO © Wiley-VCH
US researchers have produced a fully synthetic version of erythropoietin (EPO), the glycoprotein responsible for regulating blood cell production. The synthetic version includes truncated forms of all of the sugars that would naturally decorate EPO, attached at the correct positions through the correct chemical linkages. The work shows that it is now possible to synthesise individual versions of relatively large glycoproteins with well-defined carbohydrates attached, which should provide a platform to study the role of these sugars in determining the stability and function of the proteins. More...
http://www.rsc.org/chemistryworld/2012/10/erythropoietin-epo-total-synthesis-chemistry
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