Multicomponent reactions step up a gear
by
Phillip Broadwith, RSC
—
last modified
07-15-09 02:35 AM
Copyright 2009, RSC
The first reaction (red) forms an imidazoline, then the components for the second (blue) MCR are added to form an N-(cyanomethyl)-amide. The two halves are then united by benzylamine and isobutyraldehyde in an Ugi reaction
Dutch chemists have taken multicomponent reactions to the next level, combining a total of eight different starting materials in a single flask, bringing together three different multicomponent reactions and making nine new bonds in a single step. More...
http://www.rsc.org/chemistryworld/News/2009/July/14070902.asp
