Fluorination via porphyrin
by
Ian Le Guillou, RSC
—
last modified
09-14-12 07:39 AM
Copyright 2012, RSC
Despite fluorine’s popularity with medicinal chemists, reliable activation of aliphatic C–H bonds for fluorination has remained tantalisingly out of reach. Now, a manganese porphyrin has been used to selectively fluorinate sp3 carbon–hydrogen bonds using silver fluoride as a source of fluorine. More...
http://www.rsc.org/chemistryworld/2012/09/selective-fluorination-manganese-porphyrin
