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Fluorination via porphyrin

by Ian Le Guillou, RSC last modified 09-14-12 07:39 AM Copyright 2012, RSC
Fluorination via porphyrin

The proposed mechanism relies on the oxomanganese to selectively cleave C-H bonds © Science/AAAS

Despite fluorine’s popularity with medicinal chemists, reliable activation of aliphatic C–H bonds for fluorination has remained tantalisingly out of reach. Now, a manganese porphyrin has been used to selectively fluorinate sp3 carbon–hydrogen bonds using silver fluoride as a source of fluorine.  More...

http://www.rsc.org/chemistryworld/2012/09/selective-fluorination-manganese-porphyrin

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