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Flow synthesis for anticancer drug

by Michael Parkin, RSC last modified 01-23-13 07:04 AM Copyright 2013, RSC
Flow synthesis for anticancer drug

The flow-based route required minimal manual intervention and was achieved despite poor solubility of many reaction components

UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesise the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec. The method avoids the need for any manual handling of intermediates and allows the drug to be synthesised in high purity in less than a day.  More...

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