Enzymes do the twist

The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. Enzymes do not necessarily bind in the way that will most stabilise the reaction's transition state, but rather in a way which minimises the overall energy barrier for the reaction. Applying this idea to the design of new molecular catalysts could help improve their performance.  More...

http://www.rsc.org/chemistryworld/News/2010/January/06011001.asp