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DNA strides into organic synthesis

by Andy Extance, RSC last modified 10-11-10 06:30 AM Copyright, 2010 RSC
DNA strides into organic synthesis

The walking strand of DNA moves to each station (blue, red and green) in turn and reacts with the attached reagent © Nature Nanotechnol.

US scientists have used a DNA walker to synthesise an organic molecule in a series of steps, without intervention, for the first time. 

The walker, devised by David Liu and Yu He from Harvard University in Cambridge, has also achieved the highest known yield of any three-step DNA-templated small molecule synthesis to date.1 'Using the unique features of these walkers, we can direct organic synthesis in ways that are more sophisticated than is possible using simple Watson-Crick base pairing,' Liu told Chemistry WorldMore...

http://www.rsc.org/chemistryworld/News/2010/October/10101001.asp

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