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Bacterial mix sweetens biodrug synthesis
Engineering and transferring the glycosylation machinery of C. jejuni into E. coli and then using enzymes to modify the sugar portion produces homogeneously glycosylated proteins © Nature Chemical Biology
Bacteria welcome in the human gut are set to become better factories for biological drugs thanks to modified genes from another, gastroenteritis-causing, species. With this unlikely-sounding pairing, US and Swiss researchers have created the first bacterial method for making glycoproteins like those found in humans. The approach provides unprecedented control over which sugars are attached to proteins, and therefore could improve the performance of biologic drugs. More...
http://www.rsc.org/chemistryworld/News/2010/March/01031001.asp
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