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A better way to add radioactive fluorine

by Lewis Brindley, RSC last modified 08-25-10 07:32 AM Copyright 2010, RSC
A better way to add radioactive fluorine

Selectfluor, has been radiolabeled with 18F. © Angew. Chem. Int. Ed.

Making compounds that contain the useful radioisotope fluorine-18 (18F) could be much easier in future, say researchers in the UK and Finland. The team integrated the isotope into a popular fluorinating agent called Selectfluor, which opens up a wide range of chemistry to build useful radiolabelled molecules. 

18F has a half-life of around 2 hours and releases positrons as it decays, making it perfect as a radiotracer in positron emission tomography (PET). This type of medical imaging is increasingly popular for disease diagnosis and monitoring a patient's response to therapy, but it also has great potential in drug discovery.  More...

http://www.rsc.org/chemistryworld/News/2010/August/24081002.asp

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