Otava presents a new human Fibroblast Growth Factor Receptor 1 Tyrosine Kinase (FGFR1K) focused compound library.

March, 2006
Otava presents a new human Fibroblast Growth Factor Receptor 1 Tyrosine Kinase (FGFR1K) focused compound library with 1901 compounds.
This library has been created as a part of a joint project with Life Chemicals aimed at design of a large set of receptor-based sharp-focused libraries. In the framework of this project, Life Chemicals provides its Collection of 300 000 compounds and subsequent chemical optimization. Otava provides its drug-like Green Collection (50 000 compounds) and also is responsible for molecular modeling tasks.
Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
In case of this library detection of H-bonding between ligand and key FGFR1K hinge region residue (Ala564) was used for its preparation.
•About Otava
Otava supplies fine organic chemicals including unique building blocks for combinatorial organic synthesis. We provide compound libraries for screening, custom synthesis, molecular modeling services, targeted compound libraries and protein kinase inhibitors, prescreened anticancer compounds. We offer design and development of fluorescent probes, kits and reagents.
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Kyiv 187, 03187
Ukraine
Phone/Fax: +380 44 5222458
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