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Introduction to Photostability
A Practical Introduction to
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The Amorphous State and its significance for Product manufacture and Drug Delivery
| Type | Course |
|---|---|
| Language | English |
| Date |
June 7, 2006
to June 8, 2006 |
| Venue |
Thistle Westminster Buckingham Palace Road London, GB |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
Judy Callanan PharmaTraining Services 77 Leonard Street London, EC2A 4QS GB 0044 20 7613 7232 0044 20 7681 3582 judy@pharmatrainingservices.com |
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It is well known that amorphous materials have different properties to crystalline forms. This can be a bad thing if the amorphous form gives rise to batch-to-batch variability in products. Indeed small amounts of process induced amorphous content are a common cause of product and process variability. Secondly the amorphous form can be bad if it changes during shelf life, resulting in lower dissolution rate and possible bioavailability changes. However if the amorphous form can be retained during shelf life there is a real advantage for poorly soluble drugs. In this course we will study the nature of the amorphous form, how it is produced, techniques for detection and quantification, understanding of relaxation (which brings changes in properties with time), how to remove unwanted amorphous material, then how to keep wanted amorphous forms in that state and finally regulatory and IP considerations of the amorphous state.