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Introduction to Photostability
A Practical Introduction to
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Structure Based Drug Design
| Type | Course |
|---|---|
| Language | English |
| Date |
April 6, 2008
to April 7, 2008 |
| Venue |
Westin New Orleans Canal Place 100 Rue Iberville New Orleans, LA 70130 US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
ACS 1155 Sixteenth Street, NW Washington, DC , 20036 US 1-800-227-5558 ext. 4508 202-872-6336 service@acs.org |
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Learn how to use computational chemistry in medicinal chemistry, specifically to identify, refine and design inhibitors. Topics covered include: how computational methods are used in the drug discovery process; why drug-receptor interactions are important to drug efficacy; how to identify and design specific, more effective enzyme inhibitors and receptor antagonists; cheminformatics; in silico screening; and, ADME/Tox profiling.
Key Topics
* Drug Discovery, Design, and Development - drug discovery without a lead; lead discovery.
* Lead Discovery – database searching strategies; pharmacophore searching; fast docking.
* Lead Refinement – approaches for target-based and ligand-based refinement; docking and pharmacophore mapping; quantitative structure-activity relationships; molecular graphics-based drug design; examples of functional group modifications and structure modifications to increase potency and therapeutic index.
* Cheminformatics - how informatics is used to analyze compound activities and take the next step; similarity and diversity; approaches to rapidly search a corporate database for new leads.
* ADME/Tox Predictions – What makes a good drug; profiling properties of a molecule correlate with sorption, BBB, hERG, and metabolism.
Speakers
Dr. Frank Axe has over 20 years experience as a computational chemist and drug discovery scientist in the biotech and pharmaceutical industries. In the past he held positions at Accelrys, Ontogen and Johnson & Johnson. Dr. Axe is currently a faculty member at the University of the Pacific and San Joaquin Delta College both located in Northern California.
Cost
Member - $1095
Academic Member - $547.50 Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer.
Nonmember - $1245
Early Registration - Register before March 3, 2008 for the ACS Spring National Meeting Short Courses and receive $100 off the standard member/nonmember fees.
Late Registration - Registrations after March 31, 2008 for the ACS Spring National Meeting Short Courses will be assessed a $100 administrative fee.
Group Rate - Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer.