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A Pharmacology Primer for Chemists
Polymorphism in Organic/Pharmaceutical Systems
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Polymorphism in Organic/Pharmaceutical Systems
This course will meet for 8 online sessions one hour each. September 29; October 6, 13, 20, 27; November 3, 10, 17
| Type | Webinar |
|---|---|
| Language | English |
| Date |
September 29, 2009 from 02:00 pm to 03:00 pm |
| Venue |
Eastern Time , US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
American Chemical Society 1155 Sixteenth Street, NW Washington, DC 20036 US (800) 227-5558 shortcourses@acs.org |
| Add event to calendar |
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In this course, we will review the fundamentals of polymorphism, including the basics of polymorph characterization, screening, and crystallization. Polymorph changes during processing (API and drug product), the effect these changes have on development timelines, and how to minimize these changes will also be discussed. We will also cover choosing the best form for product development and how it relates to regulatory filings, patent applications, and lifecycle management.
Key Topics
* What are polymorphs and what properties may be impacted when they are part of your development project
* How to pick the best polymorph to prevent problems and delays during development
* Why polymorphism is important for intellectual property, regulatory, and lifecycle management
Session titles
1. What are polymorphs and why do we care?
2. Solid-state characterization
3. Polymorph screening
4. Thermodynamic stability of polymorphic forms and choosing the best polymorph for development
5. Developing an API crystallization process
6. Developing a formulation process
7. Process induced transformations during compound and product manufacture
8. Regulatory and intellectual property considerations