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Introduction to Photostability
A Practical Introduction to
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Pharmacokinetics and Pharmacodynamics: Principles and Applications in Pre-Clinical Drug Development
| Type | Course |
|---|---|
| Language | English |
| Date |
April 9, 2008
to April 10, 2008 |
| Venue |
Sheraton at Woodbridge Place Hotel 515 US Highway 1 South Iselin, New Jersey 08830 US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
ACS 1155 Sixteenth Street, NW Washington, DC , 20036 US 1-800-227-5558 ext. 4508 202-872-6336 service@acs.org |
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This course will help you understand the fundamental issues in pharmacokinetics and pharmacodynamics and how those issues are used in drug discovery. The course is roughly divided into factors affecting the value of the independent variables in biological experiments (drug concentration, i.e. pharmacokinetics) and factors determining the value of the dependent variable (magnitude of the biological effect). Methods to assess both of these will be discussed as well as strategies to optimize the drug discovery process from screening and drug design to final lead optimization.
Key Topics
* Principles of first-order (linear) kinetics and comparison with non-linear processes.
* Meaning and application of compartmental (vs. non-compartmental) models and their analysis.
* Definition, measurement and inter-relationships among apparent volume of distribution, plasma protein binding, clearance and half-life.
* Critical issues in drug candidate selection.
* Factors affecting oral drug absorption and bioavailability.
* Relationships between PK and PD.
* Drug metabolism issues.
* Principles of non-linearity.
* First-time dosing in humans.
* Utility of non-clinical and clinical biomarkers.
Speakers
Terry Kenakin is Principal Research Investigator Molecular Discovery in the Department of Assay Development at GlaxoSmithKline Research and Development in North Carolina. Before beginning his industrial research career, he received his training in chemistry and pharmacology at the University of Alberta in Edmonton and did post-doctoral work with the Nobel Laureate Sir James Black at the University College in London.
Cost
Woodbridge Circuit
Note - The course fee includes all course materials, continental breakfast and lunch each day.
Member - $1,095
Academic Member - $547.50 Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer.
Nonmember - $1,245
Early Registration - Register before January 14, 2008 for the Woodbridge Circuit and receive $100 off the standard member/nonmember fees
Late Registration - Registrations after February 4, 2008 for the Woodbridge Circuit will be assessed a $100 administrative fee
Group Rate - Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer.