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Mechanisms of Chemically-Induced Toxicity for Medicinal Chemistry

ACS ProSpectives Conference

Type Conference
Language English
Date May 18, 2008 to
May 20, 2008
Venue The Sheraton Society Hill| Philadelphia, PA

Philadelphia, PA
US
Chemistry Specialties
  • medicinal and pharmaceutical chemistry
  • medicine
Chemistry Techniques
  • other
Contact
ACS Perspectives

,
US


acsprospectives@acs.org
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by Daniel Fishman last modified 02-13-08 01:08 PM

Conference chairs F. Peter Guengerich, Professor of Biochemistry and the Director of Vanderbilt’s Center in Molecular Toxicology, and Dr. James MacDonald, EVP of Preclinical Development at the Schering-Plough Research Institute, have developed this program to cover the chemical basis of toxicity as it applies to medicinal chemistry. Sessions will be held on reactive metabolites and alternative mechanisms, with an emphasis on specific chemical groups and methods of screening. Numerous case studies will be given throughout the program by scientists from Pfizer, Schering Plough, and Merck, among others. The conference will also cover some newer methods and even future approaches to assessing the toxicity potential of compounds in humans, including “omics” approaches, and will provide a view of the current regulatory environment -- and therefore the level of likely acceptance of those methods.

Session titles

Gerald Miwa, formerly of Millennium, Keynote Reactive Metabolite-Mediated Toxicity: Kaushik Mitra, Department of Drug Metabolism and Pharmacokinetics, Merck on “Minimizing Metabolic Activation during Pharmaceutical Lead Optimization: Progress, Gaps and Future Directions” Amit Kalgutakar of Pfizer on “Chemical Toxicophores and Their Potential for Trouble” Mike Freeman, Prof. Radiation Oncology, Radiology, Cancer Biology at Vanderbilt University School of Medicine on “Coupling LC/MS/MS analysi