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Kinetics of Enzyme Action - Basic Principles for Drug Hunters

Type Course
Language English
Date April 5, 2008 to
April 6, 2008
Venue Doubletree New Orleans
300 Canal St
New Orleans, LA 70130
US
Chemistry Specialties
  • other
Chemistry Techniques
  • other
Contact
ACS
1155 Sixteenth Street, NW
Washington, DC , 20036
US
1-800-227-5558 ext. 4508
202-872-6336
service@acs.org
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by Lilach Zuriel last modified 02-13-08 06:22 AM

This course covers the essentials of enzyme kinetic analysis emphasizing concepts of importance in drug discovery. It provides an introduction to enzymology, assay methods, and free-energy diagrams; and also covers simple reversible inhibition and time-dependent inhibition; transition state rate theory and TS analog inhibitors; kinetics and inhibition of two substrate enzymatic reactions; screening for inhibitors of enzymatic reactions; and, probes of mechanism.

Key Topics * Enzymology, Assay Methods, and Free-Energy Diagrams * Concepts of Simple Reversible Inhibition * Time-Dependent Inhibition * Transition State Rate Theory and TS Analog Inhibitors * Kinetics of Two Substrate Enzymatic Reactions * Inhibition of Two-Substrate Enzymatic Reactions * Screening for Inhibitors of Enzymatic Reactions * Probes of Mechanism

Speakers

Ross Stein is an Associate Professor in the Department of Neurology at Harvard Medical School and Director of the Laboratory for Drug Discovery in Neurodegeneration of the Harvard Center for Neurodegeneration and Repair. Dr. Stein has been a practicing enzymologist for nearly 30 years and has published over 90 research papers on no less than a dozen different enzyme systems. Before joining Harvard in 2001, he spent 20 years building and running Enzymology and Biochemistry departments in the pharmaceutical and biotech industry.

Cost

Member - $1095 Academic Member - $547.50 Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer. Nonmember - $1,245 Early Registration - Register before March 3, 2008 for the ACS Spring National Meeting Short Courses and receive $100 off the standard member/nonmember fees Late Registration - Registrations after March 31, 2008 for the ACS Spring National Meeting Short Courses will be assessed a $100 administrative fee Group Rate - Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax, mail or phone and mention this discount and may not be combined with any other offer.

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