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Introduction to Photostability
A Practical Introduction to
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Introduction to Drug Metabolism: Role and Practice in Drug Discovery and Development
| Type | Course |
|---|---|
| Language | English |
| Date |
August 17, 2009 from 08:30 am to 05:00 pm |
| Venue |
Crowne Plaza Hotel - The Hamilton 1001 14th St NW Washington, DC 20005 US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
American Chemical Society 1155 Sixteenth Street, NW Washington, d 20036 US (800) 227-5558 shortcourses@acs.org |
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Learn about generating, interpreting, and using drug metabolism data to support drug discovery—from lead selection and optimization to drug registration.
Speakers
Dr. Donglu Zhang is a senior scientist at Bristol-Myers Squibb in Princeton, NJ. Dr. Zhang’s research interests include identification of metabolites and metabolism enzymes, investigative metabolism, LC/MS, microbial biotransformation, and their applications to drug discovery and development.
Dr. Mingshe Zhu is a drug metabolism researcher at Bristol-Myers Squibb in Princeton, NJ. His research interests include applications of new LC/MS and radiodetection technology, metabolic activation, optimization of ADME properties and regulatory drug metabolism.
Session titles
• Overview of disposition and pharmacokinetics in drug discovery Common metabolic reactions
• Common metabolism enzymes (CYP, UGT, SULT) and polymorphisms
• In vitro drug metabolism models and determination of metabolic stability
• Strategy/methodology for screening for and minimizing reactive metabolites
• CYP inhibition and induction for DDI potential
• Lead optimization examples
• Common analytical tools: LC/MS and radioactivity detection
• Metabolite identification strategies
• Reaction phenotyping
• Design of animal and human ADME studies – comparative metabolic profiling
• Regulatory considerations of drug metabolism (e.g. drug metabolites in safety testing)
• Addressing drug development issues with examples