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Introduction to Photostability
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High-Throughput Drug Analysis by LCMS
| Type | Course |
|---|---|
| Language | English |
| Date |
August 17, 2009 from 08:30 am to 05:00 pm |
| Venue |
Crowne Plaza Hotel - The Hamilton 1001 14th St NW Washington, DC 20005 US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
American Chemical Society 1155 Sixteenth Street, NW Washington, DC 20036 US (800) 227-5558 shortcourses@acs.org |
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The introduction of combinatorial chemistry technology has significantly increased the amount of compounds generated in pharmaceutical industry. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery and development to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvement to the conventional methodology must happen. High-throughput drug analysis is a new topic for drug discovery and development. This short course will mainly focus on the most recent significant advances of high-throughput analyses in the pharmaceutical industry.
Key Topics
* Introduction of the most recent significant advances of high-throughput analyses in pharmaceutical industry
* Biological sample preparation including protein precipitation, solid phase extraction, liquid-liquid extraction, Solid-phase microextractions (SPME), and Immobilized Liquid Extraction (ILE)
* The introduction and application of automated 96-well and 384-well plates for biological sample preparation
* How to choose pH buffer and mobile phase for LC
* The technique of liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS)
* How to increase throughput without sacrificing compliance
* Special topics such as the Applications of Hydrophilic Interaction Liquid Chromatography (HILIC) and monolithic Chromatography.
Who Should Attend
Target audiences for this course range from graduate students to professionals and academics in the fields of pharmaceutics and biotechnology.
Attendees should have some experience in the analytical fields.
How You’ll Benefit
After taking this course, you will learn:
* What is high throughput analysis?
* How to develop a high throughput analytical method using LC/MS?
* Why do we need high throughput analysis in the pharmaceutical industry?
* Can we survive in “low” throughput?
* What are the limitation/bottlenecks for high throughput analysis?
* Can we break the bottlenecks?
* How to perform the high throughput without sacrificing compliance?
* What are the tools for high throughput analysis?
* What is your role as an analytical chemist in the competitive pharmaceutical industry?
* Some special topics including the Applications of Hydrophilic Interaction Liquid Chromatography (HILIC) and monolithic Chromatography.
Speakers
Dr. Perry G. Wang is a chemist working for Food and Drug Administration (FDA). Before he joined FDA, he worked for pharmaceutical and medical-device companies including Abbott Labs and Teleflex Medical for more than 14 years. His interests include analytical method development and validation for pharmaceutical industry, and medicated-device products using advanced instrumentation. His expertise focuses on high throughput analysis of drugs and their metabolites in biological matrices with LC-MS/MS. Dr. Wang is an author of more than 20 scientific papers and presentations. His new book entitled "High-Throughput Analysis in The Pharmaceutical Industry" was published by CRC Press in October 2008. Dr. Wang received his BS degree in chemistry from Shandong University. He earned his MS and PhD degrees in environmental engineering from Oregon State University.
Session titles
* Introduction of the high-throughput concept
* How to validate the high-throughput method
* Introduction of high-throughput automation
* Automated liquid handler
* How to develop a high-throughput method using LCMS
* How to use the validated method to biological samples
* Application of the methods to drug discovery and development
* Two or more HPLC connected to one MS