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Introduction to Photostability
A Practical Introduction to
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Essentials of Biochemistry for Drug Hunters
| Type | Course |
|---|---|
| Language | English |
| Date |
August 19, 2009
to August 20, 2009 |
| Venue |
Four Points By Sheraton 1201 K Street, NW Washington, DC 20005 US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
American Chemical Society 1155 Sixteenth Street, NW Washington, DC 20036 US (800) 227-5558 shortcourses@acs.org |
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A review of fundamental concepts in biochemistry as applied to the process of drug discovery. Topics include: basic principles of assay development, including how to optimize parameters for high throughput screening; how to obtain and calculate important parameters of drug candidates and their limitations; criteria used for drug candidate selection; and the fundamentals of structure-aided drug design, including use of computer modeling.
Who Should Attend
* Biologists, Biochemists, and Molecular Biologists who employ assay development or run assays for high throughput screening in their day-to-day drug discovery efforts.
* Chemists who need to understand the basic principles of enzyme kinetics and receptor binding and interpret structure-activity relationship (SAR) data.
* Research managers who need a refresher on this area of critical importance to drug discovery.
How You’ll Benefit from This Course
* Obtain an overview/refresher of key concepts in Biochemistry typically taught in a full semester 400 level course.
* Learn an integrative, interdisciplinary approach to drug discovery that will allow you to be a more productive member of drug discovery project teams.
* Learn basic principles of assay development, including how to optimize parameters for high throughput screening.
* Understand the numerous criteria used for drug candidate selection.
* Understand how to obtain and calculate important parameters of drug candidates and their limitations.
* See the practical application of these principles in drug development.
* Understand the fundamentals of structure-aided drug design, including use of computer modeling.
Who Should Attend
* Biologists, Biochemists, and Molecular Biologists who employ assay development or run assays for high throughput screening in their day-to-day drug discovery efforts.
* Chemists who need to understand the basic principles of enzyme kinetics and receptor binding and interpret structure-activity relationship (SAR) data.
* Research managers who need a refresher on this area of critical importance to drug discovery.
Speakers
Jeffrey Toney is Dean of the College of Natural, Applied and Health Sciences at Kean University. Dr. Toney has over 12 years of experience in assay development in the pharmaceutical industry and his current scholarship focuses on an interdisciplinary approach to drug discovery.
Session titles
Introduction - The Process of Drug Discovery
Biochemistry Overview/Refresher
* From amino acids to 3-D structure of proteins
* Enzymes - kinetics and inhibition
* Cell signaling
* Receptor - equilibrium binding theory; agonists vs. antagonists
* Functional groups in drug molecules (pKa's), stereochemistry, and SAR
Assay Development
* Screening for enzyme inhibitors
* Screening for receptor agonists and antagonists
* Molecular docking - screening in silico
* Counterscreens - testing for specificity