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Nanoparticle fear over anti-odour socks
Fragment-based Lead Discovery Conference 2008
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Allosteric Modulator Congress
| Type | Conference |
|---|---|
| Date |
November 11, 2010
to November 12, 2010 |
| Venue |
San Diego, CA US |
| Chemistry Specialties |
|
| Chemistry Techniques |
|
| Contact |
John Waslif Arrowhead Publishers and Conferences 5412 Irving Avenue Minneapolis, MN 55419 US 312-244-3703 312-244-3703 john.waslif@arrowheadpublishers.com |
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This conference will highlight the entire drug discovery process as it pertains to the development of allosteric modulators and the challenges and recent successes associated with this exciting field. Themes include: Screening for a specific target, Hit to lead generation, Lead optimization to clinical candidate, Medicinal chemistry and Structure Activity Relationships (SARs) of allosteric modulators, Therapeutic applications of Allosteric Modulators. Background: Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may be able to offer patients better outcomes than with traditional small molecule therapies. This potential stems from their ability to offer greater selectivity and better modulatory control at disease mediating receptors. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. The advent of functional assays as the screening method of choice is leading to an increase in the number of allosteric modulators identified. Allosteric modulation is generating a great deal of excitement among researchers. Since orthosteric modulators need to compete with natural ligands, they require higher doses, raising safety issues. Allosteric modulators do not compete and may be effective at lower, safer doses.